Miskatonic University provides a coherent setting and background set in Arkham, Massachusetts in the 1920s. The world sees Miskatonic University as a solid New England institution. Its professors and departments are on par with those of any Ivy League school, among the best in the nation.

However, Miskatonic University also hides many secrets.

Chapters include Welcome to the University, Exploring the Campus, The Library and Exhibit Museum, M.U. by Department, Administrative Trivia, People at M.U., Social Life, In and Out of the Academic World, and It's The End of the World as We Know It.