Eclipse Phase: The Roleplaying Game of Transhuman Conspiracy and Horror is a post-singularity game set ten years after a technological holocaust wiped out 95% of life on Earth. The survivors escaped by electronically transmitting their brains to various habitats across the solar system. Humans now exist as electronic intelligences that can upload themselves into different bodies. Uses a percentile system based on Shadowrun Fourth Edition. The entire text (and all artwork, from the 3rd printing on) is released under a Creative Commons license, and is thus freely available (the creators seeded the initial torrent).

From the publisher:

Your mind is software. Program it.
Your body is a shell. Change it.
Death is a disease. Cure it.
Extinction is approaching. Fight it.