Seraphim Guard is an Ohio-based publisher of role-playing games and other gaming materials. Best known for publishing the shoujo anime game HeartQuest, the first commerically published role-playing game to use the Fudge system, also publishes material for the Mongoose version of Runequest and the d20 system.

In 2008, Seraphim Guard will publish the Deadworld Roel-Playing Game, the first game to license the revised Basic Role-Playing system from Chaosium Games.